Bupropion is an FDA-approved medication most commonly used to treat depression, seasonal affective disorder, and smoking cessation (as branded Wellbutrin® or Zyban®). It is also widely prescribed off-label to support weight loss—especially when emotional eating, low energy, or food-triggered dopamine spikes are a challenge.
Bupropion is a norepinephrine-dopamine reuptake inhibitor (NDRI). It increases activity in key reward and motivation pathways in the brain, helping patients feel more energetic, focused, and in control of their eating habits.
It is frequently prescribed alone or in combination with naltrexone for enhanced appetite regulation (as in Contrave®).
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When paired with a personalized weight loss plan, bupropion may help patients:
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No. Bupropion is FDA-approved for depression and smoking cessation but is commonly prescribed off-label for weight loss due to its appetite-reducing and mood-enhancing effects.
Bupropion increases dopamine and norepinephrine, two brain chemicals involved in motivation, focus, and reward. This can lead to fewer cravings, better willpower, and improved adherence to healthy eating habits.
Yes. Both are branded versions of bupropion. Wellbutrin® is typically used for depression, while Zyban® is for smoking cessation. Your provider may prescribe either, depending on your medical needs.
Yes. It’s often paired with naltrexone (as in Contrave®) or used alongside metformin or GLP-1 medications like semaglutide or tirzepatide for enhanced results. Your provider will determine the safest and most effective combination.
Bupropion is helpful for individuals who:
Dry mouth, insomnia, headache, and mild anxiety are most common, especially when first starting. These typically resolve as your body adjusts. Less commonly, it may increase blood pressure or trigger mood changes.
No. While it can improve energy and alertness, bupropion is not a stimulant, and it is not a controlled substance. It’s considered non-habit forming.
Bupropion is an FDA-approved prescription medication indicated for the treatment of depression (as Wellbutrin®) and smoking cessation (as Zyban®). It is also commonly used off-label to support weight loss in patients who may benefit from its appetite-regulating, mood-stabilizing, and energy-enhancing effects.
Off-label prescribing is a standard and legal medical practice, used when evidence supports a medication’s benefit in conditions not specifically listed in the FDA approval.
Bupropion is not suitable for everyone. It is not recommended for patients with a history of:
Bupropion may cause side effects such as dry mouth, trouble sleeping, nervousness, and headache. Rarely, it can increase the risk of seizures at higher doses. Your provider will assess your personal health history before prescribing and monitor your response throughout treatment.
Do not stop or adjust your medication without consulting your provider. Review the full Medication Guide for additional information.
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