What is Metformin?
Metformin is an FDA-approved medication most commonly used to treat type 2 diabetes. It works by improving how your body responds to insulin, reducing glucose production in the liver, and helping move sugar into your cells for energy.
In the context of weight loss, metformin is often prescribed off-label for patients who have insulin resistance, prediabetes, PCOS, or metabolic syndrome—all of which can make weight loss harder and fat storage easier.
It’s often used in combination with other medications such as GLP-1s (like semaglutide or tirzepatide), naltrexone, or bupropion for enhanced results.
What’s Included With Your Plan
- Provider Evaluation & Prescription
- Access to Metformin (from $29/month)
- Free AI-powered nutrition & fitness app
- Ongoing medical guidance and dose adjustment
* Final price to patient will depend on medication dosage and membership plan purchase.
Who can take Metformin?
✅ Adults with a BMI ≥30, or ≥27 with conditions like PCOS, insulin resistance, or prediabetes
✅ Those who don’t qualify for—or can’t afford—brand-name GLP-1s
✅ Patients seeking medically managed weight loss with ongoing support
✅ Anyone committed to sustainable, health-focused fat loss
How to get started.
Online questionnaire
Complete a secure online consultation
Medical evaluation
Your provider evaluates your goals, history & labs
Personalized plan
If appropriate, you’ll receive a Saxenda / Victoza prescription
Start your Medication
All medications come with full instructions
Ongoing support
Track your results and get support inside our AI-powered app
A few reviews from real patients
Jenna R., lost 42 lbs in 6 months
I’ve tried everything. This was the first program that worked—and the app made it simple.
David M., lost 31 lbs and reversed prediabetes
Being able to switch from brand-name to alternative saved me hundreds.
Ashley P., 38, Austin TX
I was nervous to try weight loss meds, but the provider explained everything so clearly. I’ve lost 27 lbs and feel amazing!
Marcus L., 44, Dallas CA
The app keeps me accountable and the meds actually work. I’ve dropped two sizes and finally have energy again.
Patients received compensation for sharing their experience. Results are not independently verified and may vary. Weight loss results depend on individual factors, including adherence to prescribed medication, a reduced-calorie diet, and regular physical activity.
Results You Can Expect
While metformin is not a rapid fat-burning medication, it can significantly improve your body’s ability to burn fat by correcting underlying insulin resistance. Benefits include:
- Modest, steady weight loss (especially around the abdomen)
- Reduced food cravings, especially for sugar and carbs
- Better blood sugar and insulin levels
- Less energy crashes and hunger spikes
- Improved fertility and cycle regulation (in PCOS patients)
📊 In clinical studies, metformin users lost an average of 5–10 pounds over 3–6 months, especially when combined with nutrition and physical activity support.
Pricing & Guarantee
💊 Metformin
Starting at $49/month — includes prescription, shipping, and refill coordination.
💡 Pair it with our $195/month membership for full medical support, progress tracking, and coaching.
✅ Our Guarantee: Follow your plan or we refund your monthly membership fee. (Medication cost is non-refundable.)
Get Started Today
Getting access to Metformin is simple, safe, and fast.
👉 Take the 60-second quiz
👉 Match with a provider
👉 Get personalized treatment shipped to your door
Frequently Asked Question
Is metformin FDA-approved for weight loss?
No. Metformin is FDA-approved for type 2 diabetes but is commonly prescribed off-label for weight loss in patients with insulin resistance, PCOS, or metabolic dysfunction.
How does it help with weight loss?
Metformin reduces glucose production in the liver and improves insulin sensitivity. This helps stabilize blood sugar, reduce fat storage, and lower hunger signals related to insulin spikes.
Who is it best for?
Metformin is especially helpful for patients who:
- Have prediabetes, type 2 diabetes, or insulin resistance
- Have PCOS and difficulty losing weight
- Struggle with cravings and energy crashes
- Are looking for a gentle, low-cost weight loss support medication
Is it safe to take long-term?
Yes. Metformin has been widely used for decades and is considered safe for long-term use when monitored by a healthcare provider. It does not cause hypoglycemia (low blood sugar) when used alone.
What are the side effects?
The most common side effects are nausea, diarrhea, and stomach upset, especially when starting. These usually improve over time and can be minimized by starting at a low dose or using extended-release (ER) versions.
Can I take metformin with other weight loss medications?
Absolutely. It’s often used alongside GLP-1s, naltrexone, bupropion, or low-dose naltrexone to address multiple metabolic pathways and boost results. Your provider will design the best combination for you.
How is it taken?
Metformin is typically taken once or twice daily, with food, in pill form. Most patients start on a low dose and increase gradually to minimize side effects.
Important Safety and Regulatory Information
Metformin is an FDA-approved prescription medication for the treatment of type 2 diabetes. It is also widely used off-label for weight management and hormonal/metabolic conditions such as PCOS and insulin resistance.
Off-label use is a standard medical practice, based on provider discretion and supported by clinical evidence when the medication offers potential benefits outside its original FDA indication.
Metformin is generally well tolerated, but it may cause gastrointestinal side effects (nausea, bloating, diarrhea) in some patients—especially at the beginning of treatment. Taking it with food and using the extended-release version can help.
Metformin is not recommended for individuals with:
- Severe kidney disease
- Liver disease
- Acute illness that causes dehydration
- Excessive alcohol use
A very rare but serious complication called lactic acidosis can occur in patients with kidney impairment. Your provider will evaluate your labs before starting treatment.
Metformin does not cause low blood sugar when taken alone and is not a stimulant or habit-forming. Always follow your provider’s instructions and report any side effects promptly.