What Is Low Dose Naltrexone?
Low Dose Naltrexone (LDN) is a modified, low-dose version of the FDA-approved drug naltrexone, which is traditionally used to treat alcohol and opioid dependence.
In small doses (typically 0.5 mg to 8 mg), LDN is prescribed off-label to help with appetite regulation, inflammation control, autoimmune support, and hormonal rebalancing—making it a powerful addition to medically supervised weight loss programs.
LDN works by modulating the immune system, reducing inflammation, and temporarily blocking opioid receptors, which leads to a rebound increase in endorphin and dopamine production—improving mood, motivation, and metabolism.
What’s Included With Your Plan
- Provider Evaluation & Prescription
- Access to Low Dose Naltrexone (from $59/month)
- Free AI-powered nutrition & fitness app
- Ongoing medical guidance and dose adjustment
* Final price to patient will depend on medication dosage and membership plan purchase.
Who can take low dose naltrexone?
✅ Adults with a BMI ≥30, or ≥27 with conditions like PCOS, insulin resistance, or prediabetes
✅ Those who don’t qualify for—or can’t afford—brand-name GLP-1s
✅ Patients seeking medically managed weight loss with ongoing support
✅ Anyone committed to sustainable, health-focused fat loss
How to get started.
Online questionnaire
Complete a secure online consultation
Medical evaluation
Your provider evaluates your goals, history & labs
Personalized plan
If appropriate, you’ll receive a Saxenda / Victoza prescription
Start your Medication
All medications come with full instructions
Ongoing support
Track your results and get support inside our AI-powered app
A few reviews from real patients
Jenna R., lost 42 lbs in 6 months
I’ve tried everything. This was the first program that worked—and the app made it simple.
David M., lost 31 lbs and reversed prediabetes
Being able to switch from brand-name to alternative saved me hundreds.
Ashley P., 38, Austin TX
I was nervous to try weight loss meds, but the provider explained everything so clearly. I’ve lost 27 lbs and feel amazing!
Marcus L., 44, Dallas CA
The app keeps me accountable and the meds actually work. I’ve dropped two sizes and finally have energy again.
Patients received compensation for sharing their experience. Results are not independently verified and may vary. Weight loss results depend on individual factors, including adherence to prescribed medication, a reduced-calorie diet, and regular physical activity.
Results You Can Expect
When taken consistently, and as part of a personalized treatment plan, LDN may help:
- Reduce food and alcohol cravings
Improve mood, sleep, and focus - Lower systemic inflammation and insulin resistance
- Support thyroid and hormone function (especially in PCOS or Hashimoto’s)
- Enhance the effects of other weight loss medications like semaglutide, metformin, or bupropion
📊 Patients using LDN in clinical and observational studies have reported improved appetite control, fewer binge episodes, and enhanced metabolic markers. Results vary by individual, dosage, and combination therapy.
Pricing & Guarantee
💊 Naltrexone
Starting at $59/month — includes prescription, shipping, and refill coordination.
💡 Pair it with our $195/month membership for full medical support, progress tracking, and coaching.
✅ Our Guarantee: Follow your plan or we refund your monthly membership fee. (Medication cost is non-refundable.)
Get Started Today
Getting access to Low Dose Naltrexone is simple, safe, and fast.
👉 Take the 60-second quiz
👉 Match with a provider
👉 Get personalized treatment shipped to your door
Frequently Asked Question
Is LDN FDA-approved for weight loss?
No. LDN is not FDA-approved for any specific condition. It is prescribed off-label based on emerging evidence that shows it may help with autoimmune disease, weight control, and inflammation when used at low doses.
How does LDN support weight loss?
LDN temporarily blocks opioid receptors, triggering a rebound in natural endorphins and dopamine. This leads to better mood, fewer cravings, improved control over emotional eating, and reduced inflammation—especially in metabolically resistant patients.
What’s the difference between regular naltrexone and LDN?
Regular naltrexone is prescribed at 50–100 mg/day to treat addiction. LDN uses a much lower dose—typically 0.5–4.5 mg/day—to influence immune and metabolic pathways without blocking all opioid activity.
Who benefits most from LDN?
LDN is especially helpful for patients with:
- Emotional or sugar-based food cravings
- PCOS, Hashimoto’s, or autoimmune inflammation
- Difficulty losing weight despite diet/exercise
- Insulin resistance or chronic fatigue
- Co-occurring mood symptoms like anxiety or low motivation
Can I combine LDN with other medications?
Yes. LDN is often combined with metformin, bupropion, GLP-1 medications (semaglutide/tirzepatide), or thyroid medications as part of a personalized protocol.
Are there side effects?
LDN is generally well tolerated. Some patients report vivid dreams, temporary sleep changes, or mild GI discomfort at first. These effects are usually mild and resolve with dose adjustment.
How is LDN taken?
LDN is taken orally, once daily, often at night. Dosing starts low (e.g. 0.5–1 mg) and is slowly increased over several weeks to reach the ideal level for each patient.
Important Safety and Regulatory Information
Low Dose Naltrexone (LDN) is a off-label version of the FDA-approved medication naltrexone. It is not FDA-approved for any specific medical condition and has not been evaluated by the FDA for safety, efficacy, or manufacturing standards in its form.
LDN is produced in doses far lower than the standard 50–100 mg used in addiction treatment. It is prepared by licensed pharmacies and prescribed by healthcare providers when clinically appropriate based on individual goals.
LDN is generally well tolerated but should not be used by individuals taking opioid pain medications, as it may interfere with pain relief or trigger withdrawal symptoms. Patients must disclose all current medications to their provider before starting LDN.
While side effects are uncommon, they may include:
Vivid dreams
Temporary sleep disturbance
Mild headaches or nausea
Rare allergic reaction
LDN is not a stimulant, is not habit-forming, and does not suppress appetite in the traditional sense—it works indirectly through mood, craving, and inflammation pathways.
Always follow your provider’s guidance. Do not adjust your dose or combine medications without medical supervision.