Metformin is an FDA-approved medication most commonly used to treat type 2 diabetes. It works by improving how your body responds to insulin, reducing glucose production in the liver, and helping move sugar into your cells for energy.
In the context of weight loss, metformin is often prescribed off-label for patients who have insulin resistance, prediabetes, PCOS, or metabolic syndrome—all of which can make weight loss harder and fat storage easier.
It’s often used in combination with other medications such as GLP-1s (like semaglutide or tirzepatide), naltrexone, or bupropion for enhanced results.
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While metformin is not a rapid fat-burning medication, it can significantly improve your body’s ability to burn fat by correcting underlying insulin resistance. Benefits include:
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No. Metformin is FDA-approved for type 2 diabetes but is commonly prescribed off-label for weight loss in patients with insulin resistance, PCOS, or metabolic dysfunction.
Metformin reduces glucose production in the liver and improves insulin sensitivity. This helps stabilize blood sugar, reduce fat storage, and lower hunger signals related to insulin spikes.
Metformin is especially helpful for patients who:
Yes. Metformin has been widely used for decades and is considered safe for long-term use when monitored by a healthcare provider. It does not cause hypoglycemia (low blood sugar) when used alone.
The most common side effects are nausea, diarrhea, and stomach upset, especially when starting. These usually improve over time and can be minimized by starting at a low dose or using extended-release (ER) versions.
Absolutely. It’s often used alongside GLP-1s, naltrexone, bupropion, or low-dose naltrexone to address multiple metabolic pathways and boost results. Your provider will design the best combination for you.
Metformin is typically taken once or twice daily, with food, in pill form. Most patients start on a low dose and increase gradually to minimize side effects.
Metformin is an FDA-approved prescription medication for the treatment of type 2 diabetes. It is also widely used off-label for weight management and hormonal/metabolic conditions such as PCOS and insulin resistance.
Off-label use is a standard medical practice, based on provider discretion and supported by clinical evidence when the medication offers potential benefits outside its original FDA indication.
Metformin is generally well tolerated, but it may cause gastrointestinal side effects (nausea, bloating, diarrhea) in some patients—especially at the beginning of treatment. Taking it with food and using the extended-release version can help.
Metformin is not recommended for individuals with:
A very rare but serious complication called lactic acidosis can occur in patients with kidney impairment. Your provider will evaluate your labs before starting treatment.
Metformin does not cause low blood sugar when taken alone and is not a stimulant or habit-forming. Always follow your provider’s instructions and report any side effects promptly.
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